After she was fired from "Beverly Hills 90210" for drama with the cast and crew, Shannen Doherty got her comeuppance when "Charmed" debuted in 1998. Doherty never quite charmed her co-star, Alyssa Milano, and the rumored feud likely led to Doherty's character, Prue, being killed off.
When the second season of "Good Times" started, Amos threatened to leave the show due to the negative images he felt that it portrayed of African-American culture. Unfortunately, Amos wasn't given the option to walk away, as his character was killed off.
Charlie Sheen lashed out at "Two and a Half Men" creator Chuck Lorre in angry tweets and interviews, calling him a "maggot" and allegedly making antisemitic remarks about him. In the Season 9 premiere, Lorre had Sheen's character, Charlie Harper, hit by a train and replaced by Ashton Kutcher.
Nicollette Sheridan didn't get along with "Desperate Housewives" creator Marc Cherry. After her character, Edie Britt, was killed off in April 2009, she sued Cherry and Touchstone Television for wrongful termination, and Cherry admitted that Sheridan’s "unprofessional" behavior played a role in her getting the ax.
"Sliders” star John Rhys-Davies was not a fan of the sci-fi show's writing team, referring to the scripts as "incomprehensible gibberish". He said these clashes prompted his exit midway through Season 3, insisting the writers "screwed up because they didn't have the vision."