Jamie Lee Curtis' time in Hollywood is decades-long and quite impressive, but every career has its ups and downs, and one of Curtis' biggest regrets has to do with plastic surgery. She's undergone several cosmetic procedures, including Botox and liposuction, and spoke about her worst experience in 2002.

In an interview with More, Curtis spoke about her appearance being shamed on the set of the (now ironic-sounding) 1985 film "Perfect": "I had fat taken from underneath my eyes because I was on a movie and I was puffy [...] And I can remember the cameraman saying, 'I can't shoot her.' I remember being mortified."

After the "Perfect" incident, only did Curtis get eye surgery she ended up hating; she also got an addiction to painkillers. "Right after that movie I went and had an eye job," she said. "That's when I found Vicodin, and the cycle of addiction began with that." Her final verdict on plastic surgery is that "None of it works."

Thankfully, Curtis is over her addiction and impossible beauty standards. In 2019, she spoke about appearing on the cover of More: "I said, here's the deal: I will take a picture in my underwear, with no makeup, no hair [...] my body the way it is [...] and then print the picture of me fully glammed-out on the next page”.