What Really Happened Between Vince Vaughn And Jennifer Aniston?

It seems like a million years since Jennifer Aniston and Brad Pitt split in October 2005. They were married for nearly five years and together for seven. The split rocked the world — especially once Pitt started dating his "Mr. and Mrs. Smith" co-star Angelina Jolie. We all know how that turned out. But Aniston moved on quickly and had what could be called a rebound relationship with Vince Vaughn.

Aniston and Vaughn starred together in the film "The Breakup." They met and developed a friendship during filming in 2005 — ironically, probably at just about the time her marriage to Pitt was ending. Fans wanted to see this relationship succeed — especially after Aniston had just gone through the highest-profile divorce of all time. The tabloids were full of coverage of Pitt and Jolie's relationship. Aniston's fans wanted to see her happy, and, to be honest, probably wanted to see her "stick it" to Pitt a bit.

Plus, wouldn't it be a good story to have a couple who met on a film about a breakup succeed?

Alas, it was not to be and Aniston and Vaughn broke up in the fall of 2006, per Bustle. What went wrong? Keep reading to find out.

This is how Jennifer Aniston and Vince Vaughn handled their real-life breakup

In the spring of 2006, rumors started circulating that Jennifer Aniston and Vince Vaughn were planning a secret wedding, as Aniston revealed on an episode of "Oprah" (per TMZ). That didn't turn out to be true.

The fact is, Aniston and Vaughn are busy, working actors, and a few months into their relationship the honeymoon phase was interrupted when they started their next projects, according to Bustle. That led to months away from each other, which is hard on any relationship, let alone a relatively new one.

By the fall, the relationship was kaput. The breakup was amicable and they remain friends to this day. For Aniston, Vaughn was the perfect antidote to her marriage to Brad Pitt. She called him her "defibrillator." In a 2008 interview with Vogue, Aniston said, "He literally brought me back to life. My first gasp of air was a big laugh! It was great ..."

Vaughn also has only good things to say about Aniston. But one facet of Aniston's life — or rather, her fame, he didn't love was the constant presence of the paparazzi. In an interview with Playboy (via Bustle), he said, "I never enjoyed the paparazzi side of it. You like someone and you're spending time with them ... But I really spent most of that time finding ways not to be drawn into the attention."

The relationship between Jennifer Aniston and Vince Vaughn simply ran its course.